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Metastatic Undifferentiated Pleomorphic Sarcoma on Tongue: Case Report
김윤현, 홍진호, 정재환, 김현민, 한승용, 김현실, 김형준,
소속 상세정보
김윤현 ( Kim Yoon-Hyeon ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
홍진호 ( Hong Jin-Ho ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
정재환 ( Jung Jae-Hwan ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
김현민 ( Kim Hyoun-Min ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
한승용 ( Han Seung-Yong ) - Yonsei University College of Dentistry Department of Oral Pathology
김현실 ( Kim Hyun-Sil ) - Yonsei University College of Dentistry Department of Oral Pathology
김형준 ( Kim Hyung-Jun ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
Abstract
Sarcoma is rare malignant tumors that develop from mesenchymal cells. Metastasis to the oral cavity is a rare occurrence. Undifferentiated Pleomorphic sarcoma(UPS), formerly known as Malignant fibrous histiocytoma(MFH), is rare spindle cell neoplasm that can have poorly prognosis with metastasis and local recurrence. This report describes a case of a 77-year-old man who was diagnosed with Undifferentiated Pleomorphic Sarcoma of the chest wall and underwent adjuvant radiation therapy after surgical resection. Although there was success of wide excision, two years later, he presented with metastasis to the several organs including tongue. We retrospectively analyzed results of Next Generation Sequencing(NGS), and we figured out RB1 gene mutation. Until now targeted therapy of RB1 gene mutation is not established. Surgeon needs to consider metastatic tumors through identifying patients’ chief complaints and past medical & dental history. We need to research through NGS, and take a step closer to find targeted therapy for tumors.
키워드
UPS; Undifferentiated Pleomorphic Sarcoma; RB1; Tongue metastasis; Metastatic sarcoma
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